In recent years the cannabis industry has been rapidly growing and there has been an increasing demand for Cannabis-based products, both for medicinal and recreational purposes. The legalization of medicinal Cannabis in 2018 in Portugal and other countries has challenged the traditional views and attitudes towards the use of cannabis, and this trend is likely to continue. What are the current attitudes and perceptions of the general public, medical professionals, and other stakeholders towards the use of medicinal Cannabis in Portugal? What are the main reasons for the resistance, and how can these be addressed? How can the use of medicinal Cannabis be regulated in a way that ensures its safe and effective use, while also promoting its acceptance among the public and medical professionals?